179 12.5 Vitamin K
There are 3 forms of vitamin K. Phylloquinone (K1), the plant form of vitamin K, is the primary dietary form of vitamin K. Its structure is shown below.
Green leafy vegetables, broccoli, Brussels sprouts, and asparagus are foods that are good sources of phylloquinone2.
Another form of vitamin K, menaquinone (K2), is synthesized by bacteria in the colon. Menaquinone comprises ~10% of absorbed vitamin K every day and can also be found in small amounts in animal products. Its structure is shown below3.
In the structure above, if it was menaquinone-8, there would be 7 (8-1) repeating units of the structure inside the brackets above.
The synthetic form of vitamin K is menadione (K3), whose structure is shown below.
A tail, similar to the one found in menaquinone, has to be added to menadione for it to be biologically active.
Vitamin K is absorbed like other fat-soluble substances. Approximately 80% of phylloquinone and menaquinone are incorporated into chylomicrons and stored primarily in the liver2,6. Once metabolized, vitamin K is primarily excreted via bile in the feces, with a lesser amount excreted in urine6.
Subsections:
12.52 Vitamin K Deficiency & Toxicity
References & Links
1. http://en.wikipedia.org/wiki/File:Phylloquinone_structure.svg
2. McGuire M, Beerman KA. (2011) Nutritional sciences: From fundamentals to food. Belmont, CA: Wadsworth Cengage Learning.
3. Byrd-Bredbenner C, Moe G, Beshgetoor D, Berning J. (2009) Wardlaw’s perspectives in nutrition. New York, NY: McGraw-Hill.
4. http://en.wikipedia.org/wiki/File:Menaquinone.svg
5. http://en.wikipedia.org/wiki/File:Menadione.png
6. Gropper SS, Smith JL, Groff JL. (2008) Advanced nutrition and human metabolism. Belmont, CA: Wadsworth Publishing.
